About Sickle Cell Disease | Sickle Cell Disease (SCD) | CDC
People with SCD may start to have signs of the disease during the first year of life, usually around 5 months of age. Symptoms and complications of SCD are different for each person and can range from mild to severe.

Sickle Cell Disease (SCD) Symptoms, Causes & Types
Sickle cell disease (SCD) is an inherited blood disorder. It causes your red blood cells to form into a “C” shape. It can cause pain and serious complications.

Sickle Cell Disease (SCD) | Sickle Cell Disease (SCD) | CDC
Featured Data and Statistics Find sickle cell disease-related data and statistics on prevalence, complications, and more.

What Is Sickle Cell Disease? - NHLBI, NIH
Sickle cell disease is an inherited blood disorder that affects hemoglobin, the protein that carries oxygen through the body. Misshapen red blood cells can block blood flow causing lifelong health problems.

Sickle cell anemia - Symptoms & causes - Mayo Clinic
Sickle cell anemia is one of a group of inherited disorders known as sickle cell disease. It affects the shape of red blood cells, which carry oxygen to all parts of the body. Red blood cells are usually round and flexible, so they move easily through blood vessels.

Sickle cell disease - Wikipedia
In sickle cell disease, low oxygen tension promotes red blood cell sickling and repeated sickling episodes damage the cell membrane and decrease the cell's elasticity.

Sickle-cell disease - World Health Organization (WHO)
Sickle-cell disease is a serious inherited blood disorder caused by a mutation in the HBB gene, leading to abnormal, sickle-shaped red blood cells that block blood flow and cause severe health complications.

Sickle cell disease - The Lancet
This Seminar provides a comprehensive update on the disease, emphasising its complex pathophysiology involving sickle haemoglobin polymerisation, vaso-occlusion, haemolysis, and inflammation that lead to acute, life-threatening complications and progressive organ damage.

Sickle Cell Disease - Causes and Risk Factors | NHLBI, NIH
Sickle cell disease is a genetic disorder caused by mutations in hemoglobin genes, leading to a faulty hemoglobin protein, called hemoglobin S. Hemoglobin S changes flexible red blood cells into rigid, sickle-shaped cells. The sickled cells can block blood flow and cause pain and organ damage.

Sickle Cell Disease - MedlinePlus
Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.