Gene amplification - Wikipedia
Gene amplification refers to a number of natural and artificial processes by which the number of copies of a gene is increased "without a proportional increase in other genes". [1]

基因扩增 - 百度百科
基因扩增（gene amplification）是指某一个特定基因的 拷贝数 选择性地增加而其它基因的拷贝数并未按比例增加的过程 [1] 。 基因扩增产生的可能原因： 1、由错误的 DNA复制 和修复导致的 基因复制 。

Gene Amplification - an overview | ScienceDirect Topics
Gene amplification is a selective increase in the number of copies of a gene sequence without a proportional increase in other genes. FGFR gene amplification causes ligand-independent signaling.

Gene amplification - Latest research and news - Nature
Gene amplification is an increase in the number of copies of a gene without a proportional increase in other genes. This can result from duplication of a region of DNA...

Understanding the Difference: Gene Amplification vs ... - Genetics
One key difference between gene amplification and overexpression is that gene amplification involves the duplication of specific DNA regions, resulting in an increased number of gene copies. On the other hand, gene overexpression refers to the increased production of mRNA and proteins from the existing gene copies.

Gene Amplification - National Human Genome Research Institute
Gene amplification refers to an increase in the number of copies of a gene in a genome. Cancer cells, for example, sometimes produce multiple copies of a gene(s) in response to signals from other cells or the environment.

Mechanisms of Gene Duplication and Amplification - PMC
Duplications, and especially their derived amplifications, are suggested to form by multistep processes often under positive selection for increased copy number. Gene duplications are one of the oldest and most frequent types of mutation. Genetic approaches are being used to dissect the mechanisms by which they form.

Gene Amplification - an overview | ScienceDirect Topics
Gene amplification is defined as the differential increase in a specific portion of the genome compared to the rest, which can occur in various organisms and cell types. It may play a role in normal development or lead to consequences such as tumor formation in cases of somatic cell gene amplification, particularly in cancer research.

Recent advances and application of whole genome amplification in ...
Gene amplification in tumor cells is the main mechanism of oncogene activation. 119 Oncogene activation can cause tumor cells to escape growth inhibition and produce drug resistance. 120 As a genetic disease, gene diagnosis and analysis of cancer individuals are essential for the guidance and realization of individualized therapy but proves ...

Gene Amplification - an overview | ScienceDirect Topics
4.3.2 Gene amplification. Gene amplification is an expansion of a gene copy number within the genome of a cell. The amplified DNA segment usually involves several hundred kilobases and can contain many genes. Members of four different oncogene families (c-Myc, cyclin D1, EGFR, and Ras) are often amplified.